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	Provedor de dados Anais da ABC (AABC) (1) Biol. Res. (1) Autor Calcagnotto,Maria Elisa (1) Cristina G.,Massant (1) Gabriela F.,Barnabé (1) Guimarães,Alessander O. (1) Jang,Yongwoo (1) Kim,Eun-Kyung (1) Kim,Sung Min (1) Mello,Luiz E. (1) Motta,Fabiana L. (1) Pesquero,João B. (1) Schwindt,Telma T. (1) Shim,Won-Sik (1) Song,Ki-Min (1) Mais... Palavra-chave Neurosphere (2) Amniotic fluid (1) Differentiation (1) Epidermal growth factor (1) Extracellular signal-regulated kinase (ERK) (1) Fetal development (1) Fibroblast growth factor 2 (1) Glycogen synthase kinase-3 (GSK-3) (1) Neural clustering (1) Neural precursor cells (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2015 (1) 2009 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Amniotic fluid exerts a neurotrophic influence on fetal neurodevelopment via the ERK/GSK-3 pathway Biol. Res. Jang,Yongwoo; Kim,Eun-Kyung; Shim,Won-Sik; Song,Ki-Min; Kim,Sung Min. BACKGROUND: The fetus is surrounded by the amniotic fluid (AF) contained by the amniotic sac of the pregnant female. The AF is directly conveyed to the fetus during pregnancy. Although AF has recently been reported as an untapped resource containing various substances, it remains unclear whether the AF could influence fetal neurodevelopment. RESULTS: We used AF that was extracted from embryos at 16 days in pregnant SD rat and exposed the AF to the neural cells derived from the embryos of same rat. We found that the treatment of AF to cortical neurons increased the phosphorylation in ERK1/2 that is necessary for fetal neurodevelopment, which was inhibited by the treatment of MEK inhibitors. Moreover, we found the subsequent inhibition of glycogen synthase... Tipo: Journal article Palavras-chave: Amniotic fluid; Extracellular signal-regulated kinase (ERK); Glycogen synthase kinase-3 (GSK-3); Neural clustering; Neurosphere; Fetal development. Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100044 Effects of FGF-2 and EGF removal on the differentiationof mouse neural precursor cells Anais da ABC (AABC) Schwindt,Telma T.; Motta,Fabiana L.; Gabriela F.,Barnabé; Cristina G.,Massant; Guimarães,Alessander O.; Calcagnotto,Maria Elisa; Pesquero,João B.; Mello,Luiz E.. Cell therapy for neurological disorders has advanced, and neural precursor cells (NPC) may become the ideal candidates for neural transplantation in a wide range of diseases. However, additional work has to be done to determine either the ideal culture environment for NPC expansion in vitro, without altering their plasticity, or the FGF-2 and EGF mechanisms of cell signaling in neurospheres growth, survival and differentiation. In this work we evaluated mouse neurospheres cultured with and without FGF-2 and EGF containing medium and showed that those growth factors are responsible for NPC proliferation. It is also demonstrated that endogenous production of growth factors shifts from FGF-2 to IGF-1/PDGFb upon EGF and FGF-2 withdrawal. Mouse NPC cultured in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neural precursor cells; Neurosphere; Fibroblast growth factor 2; Epidermal growth factor; Differentiation. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300009 Registros recuperados: 2 Primeira ... 1 ... Última

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